Analysing aspirin tablets by HCL acid.

Data Collection

Trial 1st attempt±0.01 2nd attempt± 0.1 3rd attempt ±0.1cm

Initial 0cm 0cm 10.7cm 21.1cm

Final 10.15cm 11.7cm 21.1cm 31.35cm

Mean/Titre 10.625cm

Burette - Hydrochloric Acid (0.10 mol dm?")

Burette error - ± 0.1ml

Pipette solution - Aspirin Solution

Pipette error - ± 0.06ml

Indicator - Phenolphthalein (colour change in the aspirin solution from colourless to pale pink)

Data Processing and Presentation

NaOH = 1.0M before hydrolysis of aspirin

HCl = 0.1M

25cm" of aspirin solution = 1.0M of NaOH

NaOH at start = (1.0/1000) x 25 = 0.025 mol dm"

1 aspirin = 2NaOH

Aspirin tablets Molar mass = 180.17g

M = g/Mr

G = M x Mr

(0.1/1000) x 10.625 (titre) = 0.001625 x 10 = 0.01625M

moles in start (0.025) - moles NaOH (0.01625) = 0.00875 / 2 = 0.00438 mol dm" of NaOH in

Moles of NaOH 0.00438 x 180.17 = 0.789g of Aspirin

Fig 8. Titration of NaOH with 1 mol/L HCl

diagram showing the chemical synthesis of aspirin

Representation 3D de la soude caustique (NaOH)

1.5g of tablets contains 0.789g of aspirin so, (0.789/1.5) x 100 = 52.6% of aspirin in 1.5g of tablets.

Conclusion and Evaluation

From the results above the experiment seem to appear as quite accurate but due to a source of error caused by pouring too much dilute water into the aspirin solution, above the original 250cm" mark, therefore having to pour some out caused a loss of NaOH as well, thereby making the results inaccurate and unreliable to an extent. The reason why the percentage of aspirin present in the 25cm" is around 50% and not around 70/80% as it should be is due to the fact that more then 250cm" of solution was formed where some of it was poured out making the a certain percentage of the aspirin slip out as well.

The procedure was quite well but due to the sources of error such as the glassware...