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Radiation Oncology Therapy Comparison Algorithm
The aim of the study was to compare and validate a new dosage calculation algorithm, Acruros XB (AXB). Validation will be used to determine the effectiveness of AXB for computing dosage for radiation therapy, which is used in Eclipse treatment plans (TPS). An evaluation will be made by comparing the doismetric AXB data with an anisotropic analytical algorithm called AAA, using RTOG 0813 factors. The RTOG 0813 factors are used because stereotactic body radiation therapy (SBRT) requires the use of dosage calculation algorithms that are capable of heterogeneity corrections for dosage computations. The study also was used to evaluate the accurateness of AAA and AXB for dosage prediction. The evaluation was designed to expand further than low-density mediums of diverse widths and compare data measurements.
In the RTOG study for dosimetric, 14 clinically accepted SBRT NSCLC cases were used.
The planning target volume (PTV) selected was between 3.2-43 cc. After RTOG 0813 dosimetric standards, treatment procedures for RapidArc were produced in Eclipse TPS. Treatment procedures were designed with AAA, which included correction for heterogeneity. AAA plans were re-calculated with AXB, which included correction for heterogeneity. The re-calculation ensured beam parameters were identical and contained an equal amount of monitor units. Comparisons between AXB and AAA plans included the following parameters for RTOG 0813: prescription isodose volume ratio with PTV (R100%), prescription isodose volume at 50% ratio with PTV (R50%), prescription dosage percentage of max dosage of 2 cm from the PTV in whichever direction (D2cm), and ipsilateral lung percentage for receiving dosage equal to or greater than 20 Gy (V20).
Results from the phantom study revealed that the data obtained for AXB had measurements that were in better agreement...