The effects of tetracycline on chick embryos

Essay by dean towerUniversity, Master'sA+, December 1996

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Professor J. P. Ellis

T.A. Tom Pinard

Bryan Dumanski

Mike Hale

Dean Tower

Heather Mammon

Joe Hull

July 15, 1996


Our Embryology lab experiment was performed to observe the effects of tetracycline on

the development in chicken embryos, such as bone and beak growth. Five control and

seven experimental eggs were used for the experiment. The five control eggs were not

injected with tetracycline, six of the experimental eggs were injected with 0.05 mg of

tetracycline, and one of the experimental eggs was injected with 0.2 mg of tetracycline.

On the seventeenth day of embryo development, all eggs were opened and observed.

Good conclusive results were noted. Out of the seven injected eggs, all had some sort

of abnormality. Conversely the control group eggs appeared normal.

Table of Contents

I. Introduction

II. Methodology

III. Results and Observations

IV. Discussion and Conclusion

V. Bibliography

I. Introduction and Review

Tetracycline, an antibacterial drug, is used to treat many infectious diseases such as

gonorrhea, syphilis, sinusitis, upper respiratory infections.

The usual adult dosage ranges from 100mg to 200mg once a day. Possible allergic

reactions include: 1) swelling of the face, 2) skin rash, 3) loss of appetite with vomiting,

4) soar throat, and 5) abdominal cramping. There are more serious side effects , such

as anaphylactic reactions, liver and renal damage, discoloration of teeth with

malformation in children under 8 years of age.

Results of animal studies shows that tetracycline class drugs cross the placenta and

are found in fetal tissues. This has toxic effects on developing fetuses. These effects

include retardation of skeletal development, decreased white cells, and increased

eosionophils. Due to the findings, it is advisable to completely avoid tetracycline class

drugs during pregnancy and breast feeding.

Tetracycline drugs...