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Doi: 10.2967/jnumed.114.141705 Published online: August 28, 2014.

2014;55:1567-1572.J Nucl Med.

David M. Wilson and John Kurhanewicz

C MR for Molecular Imaging of Prostate Cancer13Hyperpolarized

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F O C U S O N M O L E C U L A R I M A G I N G

Hyperpolarized 13C MR for Molecular Imaging of Prostate Cancer

David M. Wilson and John Kurhanewicz

Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California

Hyperpolarization using dissolution dynamic nuclear polarization has emerged as a versatile method to dramatically improve the MR signal of low-sensitivity nuclei. This technique facilitates the study of real-time metabolism in vitro and in vivo using 13C- enriched substrates and has been applied to numerous models of human disease. In particular, several mechanisms underlying prostate cancer have been interrogated using hyperpolarized 13C MR spectroscopy. This review highlights key metabolic shifts seen in prostate cancer, their study by hyperpolarized 13C MR spectroscopy, and the development of new platforms for meta- bolic study.

Key Words: PET/MR imaging; PET/MRI; 13C-magnetic reso- nance; prostate; prostate cancer; hyperpolarized 13C; metabolism

J Nucl Med 2014; 55:1567-1572 DOI: 10.2967/jnumed.114.141705

The recent first-in-man hyperpolarized 13C MR imaging study in prostate cancer patients has confirmed the...