Many movies are derived from novels, and all of them have major differences from the book version. While there are many similarities in the movie and the book Of Mice and Men, there are many differences also. Some differences are presented through the characters, scenes, and the way the actors play their roles.
The book portrayed the opening scene as a setting on the Salinas River, with one side having foothills leading up to the Gabilan mountains. The other side was the valley that was covered with trees. The movie shows the incident in Weed where the girl Lennie grabbed was running after George and Lennie. In the book, it never mentions that there were some dogs who helped chase them out of town, it was only a few guys.
However, the movie shows that there were actually some dogs chasing George and Lennie. The part where George throws the mouse in the brush was in the day in the movie, but at night in the book.
Also in the opening sequence of the book, there wasn't a train, but in the movie, they showed one steaming along.
Lennie was someone who didn't know what to do, and just made terrible choices in the book. Lennie was portrayed as someone retarded in the movie. The book made no mention of any talking disorders or actual disabilities. The beginning the movie showed Lennie as just a follower of George. As the movie progressed, he still was a follower of him, but he seemed to mature and was able to make better choices. In the scene where Lennie kills Curley's wife, he made the good decision to try to keep away from her.
Many times he said that he didn't want to talk to her, and doesn't want any...