Sickle Cell Anemia

Essay by ProCrastinAte151University, Bachelor'sA-, December 2006

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This is about Sickle Cell Anemia all i was asked to do was look stuff up about it and turn it into an essay no works cited sheet was nesscary!

Sickle Cell Anemia is an inherited disorder in which red blood cells contain an abnormal form of hemoglobin, a protein that carries oxygen. The abnormal form of hemoglobin causes the red blood cells to become sickle-shaped. The misshapen cells may clog blood vessels, preventing oxygen from reaching tissues and leading to pain, blood clots and other problems. Sickle cell anemia is most common in people from African descent and in people from Italy, Greece, India, and the Middle East.

Sickle Cell Anemia is the specific name of a form of sickle-cell disease in which there are two of the same alleles (position on DNA) that mutates and causes Hgb S which includes sickle-hemoglobin C, sickle beta-plus-thalassemia, sickle beta-zero-thalassemia, and hemoglobin ss.

These other forms of sickle-cell disease are compound heterozygous states in which the person has only one copy of the mutation that causes Hgb S and one copy of another abnormal hemoglobin gene. Sickle-cell disease is a non-specific term. Because the different forms of sickle-cell disease are quite different, one must specify the exact form of the type of sickle cell disease in question. Sickle-cell anemia is the proper name of a specific type of sickle-cell disease.

Genes for sickle cell are inherited in pairs, one copy from each parent. Therefore, each person has two copies of the gene that makes beta-globin. As long as a person inherits one normal beta-globin gene, the body can produce sufficient quantities of normal beta-globin. A person who inherits a copy of each of the normal and abnormal beta-globin genes is referred to as a carrier of the sickle cell trait. Generally, carriers...