Steroidal anti inflammatory drugs (NSAIDS), health risks, and psychological implications.

Essay by mambueUniversity, Master'sA-, October 2008

download word file, 4 pages 3.0

What is non steroidal anti inflammatory drugs (NSAIDS), and is it legal according to WADA?Non-steroidal anti-inflammatory drugs are also simply known as NSAIDs. These are agents which have analgesic (pain relief), antipyretic (reduce fever) and, anti-inflammatory (ameliorate inflammatory actions like redness, swelling etc) effects. The term "non-steroidal" is used so that we can distinguish them from steroids, act similarly in terms of effects of pain relief and the anti-inflammatory action, though the mechanism of action is different. NSAIDs are non-narcotic (do not belong to opioid group of drugs). NSAIDs are also alternatively known as non-steroidal anti-inflammatory agents/analgesics (NSAIAs) or non-steroidal anti-inflammatory medicines (NSAIMs) (Rossi, 2006). Amongst the most well known and commonly used agents or group of drugs are aspirin, ibuprofen, and naproxen. These drugs are not banned as per the WADA ( The typical NSAIDs are non-selective Cyclooxygenase inhibitors, in that they inhibit both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes.

The normal action of the enzyme Cyclooxygenase is that it catalyzes the formation of prostaglandins and thromboxane from arachidonic acid. Prostaglandins along with a lot of other agents, is one of the main agents responsible for the effects of inflammation in the body (Rossi, 2006) .

Physiologically how does the non steroidal anti inflammatory drugs (NSAIDS) effect the body- be as specific as possible, but also make sure you understand what you are writing. If the aid has a medical use (ex- testosterone) then briefly discuss this too.

These drugs are commonly categorized as nonselective NSAIDs and the COX-2 inhibitor specific agents. Some of the nonspecifics NSAIDs are diclofenac, flurbiprofen, ibuprofen, ketorolac, nabumetone , naproxen , naproxen sodium and a few others. The more common COX-2 specific drugs are celecoxib and rofecoxib. The difference between these two agents is that the nonselective NSAIDS...